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The reversed sequence combined with D-amino acids produces a mirror-image topology that is functionally equivalent to the native FOXO4 binding domain for protein-protein interaction disruption, a design strategy validated in the landmark 2017 Cell study
Tolo has a different approach
The SURMOUNT-1 trial, also in the New England Journal of Medicine, studied tirzepatide in adults with obesity or overweight without type 2 diabetes
Peng, B
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